Efficacy and toxicity of treatment of smoldering multiple myeloma: a systematic review and meta-analysis.

ABSTRACT:

Objective

Smoldering multiple myeloma (SMM) is a slowly progressive, asymptomatic plasma cell disorder. This meta-analysis evaluated the efficacy and safety of novel agent-based therapies for SMM, particularly high-risk patients.

Methods

PubMed, Embase, Web of Science, Ovid MEDLINE, Scopus and ClinicalTrials.gov were searched for randomized controlled trials (RCTs) and non-randomized studies from 2003 to 2024.

Results

Nineteen studies were included, comprising 5 RCTs and 14 non-randomized, single-arm trials. These studies involved a total of 1217 patients. Pooled analysis of intervention groups showed progression-free survival (PFS) and overall survival (OS) rate at 12 months of 94% (95% CI, 89%-98%) and 99% (95% CI, 97%-100%), respectively. The overall response rate

SUBMITTER: Quan L 

PROVIDER: S-EPMC12466189 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature