Integrative multi-omics analysis deciphers the regulatory mechanisms of egg weight traits in chickens.

ABSTRACT: Egg weight is an economically important trait in the chicken, and affects the hatchability and chicks' performance in broiler breeding programs. Our comprehensive analysis of 22,375 chickens revealed that the hens' egg weight was linked to their body weight, egg production and hatchability, with higher egg weight potentially increasing the body weight and delaying the female sexual maturity. Egg weight is a dynamic trait, however, previous studies usually focused on single time point and overlooked the dynamic changes during egg-laying period. We performed both single and longitudinal genome-wide association studies in 2,350 hens, combining selective sweep analysis, to identify genetic variants. Then, we integrated multi-omics data of 40 chickens to determine key genes and metabolites. A m

SUBMITTER: Ding J 

PROVIDER: S-EPMC12466229 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature