Transcriptional and endocrine orchestration of medullary bone formation and mineral turn-over in female chickens.

ABSTRACT: Medullary bone is deposited in the cavities of avian long bones and serves as a calcium reservoir for successful eggshell mineralization in sexually mature female chicken. Osteoblasts and osteoclasts located in medullary bone respond to endocrine changes, including high estrogen levels at sexual maturation, and represent important targets for improving mineral turn-over in laying hens. In this study, weekly samples of blood and femur to extract medullary bone material were taken from Lohmann Brown (LB, n = 54) and Lohmann Selected Leghorn (LSL, n = 54) hens from pullet stage (week 16 of age) until onset of oviposition (week 24). Blood beta CTX-1 (C-terminal telopeptides of type I collagen) levels increased in week 17 (LSL) and week 18 (LB) until week 21, indicating organic matrix breakdown

SUBMITTER: Oster M 

PROVIDER: S-EPMC12466242 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature