Stereotactic body radiotherapy for spine and non-spine bone metastases in prostate carcinoma - a multicenter cohort analysis.

ABSTRACT:

Background and purpose

Metastases-directed radiotherapy plays an increasing role in oligometastatic prostate cancers (OMPC). Here, we investigated the role of stereotactic body radiotherapy (SBRT) for spine and non-spine bone metastases (BoM) from prostate cancer in a large real-world multicenter cohort.

Material and methods

This multicenter cohort analysis from five tertiary cancer centers included patient data of spine and non-spine BoM irradiated between 2010 and 2024. Overall survival (OS), progression-free survival (PFS), local recurrence-free survival (LRFS), SBRT target volumes and doses, toxicity, and the role of additional systemic therapies were evaluated retrospectively.

Results

231 patients (341 BoM) with median follow-up time of 28.3 months were included.

SUBMITTER: Nagler F 

PROVIDER: S-EPMC12466248 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature