Chromatin deactivation in pregranulosa cells contributes to primordial follicle formation.

ABSTRACT: The establishment and maintenance of the primordial follicle (PF) pool are critical for determining the ovarian reserve in females, ensuring efficient oocyte production, particularly in farm animals such as egg-laying chickens. This process involves the breakdown of germ cell cysts and the encapsulation of individual oocytes by somatic pregranulosa cells (pre-GCs) to form PFs, which then enter a lasting state of dormancy. The proper development of pre-GCs is essential for their interaction with and protection of oocytes, facilitating successful follicle formation. How pre-GCs organize to regulate PF formation and thesubsequent quiescence entry remain poorly understood. This study investigated gene expression and chromatin regulation in chicken pre-GCs during the PF establishment to identif

SUBMITTER: Wang X 

PROVIDER: S-EPMC12466267 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature