Oxidative Stress-Mediated DNA Damage Induced by Ionizing Radiation in Modern Computed Tomography: Evidence for Antioxidant-Based Radioprotective Strategies.

ABSTRACT: Computed tomography (CT) is fundamental to modern medicine, yet ionizing radiation (IR) exposure causes DNA damage. Although often underestimated, at current doses, CT may account for ~5% of new cancer diagnoses. Complementary radioprotective approaches beyond dose reduction are needed. We conducted a prospective observational study to characterize IR-induced oxidative stress (OS)-mediated DNA damage in modern CT to explore potential antioxidant-based radioprotective strategies. In volunteers not exposed to IR (A_NONE) and in patients with two-phase abdominal-pelvis CT (B_EXPOSURE), blood samples were collected at T_BASE-min 0 and T_POST-min 60 to measure biomarkers of OS (oxidative damage and antioxidant capacity) and DNA damage. Thirty-five subject

SUBMITTER: Ramos B 

PROVIDER: S-EPMC12466383 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature