Selective Antimicrobial Chitosan Films Incorporating Green-Synthesized Silver and Copper Oxide Nanoparticles for Acne Treatment.

ABSTRACT: Background/Objectives: Chitosan-based films incorporating green-synthesized silver nanoparticles AgNPs) or copper oxide nanoparticles (CuONPs) were developed to compare their selective antimicrobial action for topical applications. While AgNPs are known for broad-spectrum activity, this study hypothesized that CuONPs would exhibit superior, targeted efficacy against the acne-associated bacterium Cutibacterium acnes. Methods: Nanoparticles were synthesized using Camellia sinensis extract and characterized. Antimicrobial activity was evaluated using Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) assays. Chitosan films containing AgNPs or CuONPs were further tested for selective antimicrobial activity and fibroblast cytocompatibility.

SUBMITTER: Reis RAD 

PROVIDER: S-EPMC12466391 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature