Genomic Analysis of MRSA for Evaluating Local Transmission Dynamics in Geriatric Long-Term Care Facilities in Japan.

ABSTRACT: Background/Objectives: Methicillin-resistant Staphylococcus aureus (MRSA) colonization in geriatric long-term care facilities (LTCFs) is a global concern. However, the transmission dynamics of MRSA among LTCF residents in Japan remain largely unknown. Methods: Whole-genome sequencing was conducted on 85 MRSA isolates obtained from 76 residents across 4 geriatric LTCFs in Japan. Single-nucleotide polymorphism (SNP) analysis was performed to identify the transmission dynamics, with a threshold of ≤15 pairwise core-genome SNP distances defining recent transmission clusters (genomic clusters). Antimicrobial susceptibility testing and investigation of antimicrobial resistance genes were also performed. Results: Among the 76 MRSA-carrying residents, 34 (44.7%) belonge

SUBMITTER: Suzuki T 

PROVIDER: S-EPMC12466431 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature