Oxidative Stress and Inflammation in Uterine-Vascular Adaptation During Pregnancy.

ABSTRACT: During pregnancy, uterine circulation undergoes profound structural and functional adaptations to accommodate the dramatically increased metabolic demands of the growing fetus. Oxidative stress (OS) and inflammation have emerged as central regulators both physiologically, to drive vascular remodeling and angiogenesis, and pathologically, when dysregulated, to promote endothelial dysfunction, maladaptive extracellular matrix (ECM) remodeling, and heightened arterial stiffness. This review synthesizes insights into the molecular sources of reactive oxygen species (ROS) in the uterine vasculature, endothelial and immune-mediated inflammatory pathways, the bidirectional crosstalk between OS and inflammation, and their combined impact on vascular stiffness. We further discuss clinical implicati

SUBMITTER: Mandala M 

PROVIDER: S-EPMC12466448 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature