Genomic Epidemiology of Vancomycin-Resistant <i>Enterococcus faecium</i> Isolates with Full and Truncated <i>vanA</i> Operons from Russian Hospitals.

ABSTRACT: Background: Vancomycin-resistant Enterococcus faecium (VREfm), particularly vanA-positive strains, represents a growing threat in hospital settings worldwide. These bacteria are able to survive under severe environmental conditions, including high temperatures and saline concentrations. High genome plasticity and advanced ability of inheriting antimicrobial resistance determinants defined the success of E. faecium as a hospital pathogen. Methods: This study presents the whole genomic characterization of vanA-positive VREfm isolates, analyzing 10 clinical isolates collected from three tertiary care hospitals in Moscow, Russia. Several typing approaches, including two MLST schemes and cgMLST profiles, were used to elucidate the relationship between t

SUBMITTER: Slavokhotova A 

PROVIDER: S-EPMC12466474 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature