High-Fat-Diet-Induced Kidney Injury in Rats: The Role of Tart Cherry Supplementation.

ABSTRACT: The kidney plays a crucial role in the complex inter-organ communication that occurs during obesity, leading to the development of oxidative stress, inflammation, and fibrosis. Dysfunction of the transient receptor potential (TRP) ion channels contributes to this pathophysiology. This study was designed to evaluate the effects of antioxidant-rich fruit tart cherry (Prunus cerasus L.) on kidney morphology and protein expression in rats with diet-induced obesity (DIO). Methods include histological staining and immunohistochemical and Western blot assays. Obese rodents were fed with seed powder (DS) and seed powder plus juice (DJS) of the tart cherry. Results demonstrated that rats fed a high-fat-diet (HFD) showed a significant reduction in renal expression of the pro-inflammatory cyto

SUBMITTER: Martinelli I 

PROVIDER: S-EPMC12466484 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature