Bacterial microbiome profiles of the inflamed terminal ileum mucosa in active Crohn's disease patients.

ABSTRACT:

Background

The dysbiosis of the intestinal microbiome relates to the pathogenesis of Crohn's disease (CD). Previous studies have focused on microbiota diversity and composition in CD patients in comparison with healthy individuals. Nonetheless, intestinal flora varies greatly among individuals. This study aimed to characterize the bacterial microbiome profiles of inflamed mucosa in comparison with those of noninflamed mucosa from Crohn's disease patients.

Methods

Sequencing of 16S rDNA V4 was used to identify the bacterial microbiome profiles of twelve pairs of inflamed and noninflamed mucosa from active CD patients.

Results

A total of 753 OTUs were specific to inflamed tissues. Alpha diversity demonstrated that the biodiversity of the bacterial microbiota in the infl

SUBMITTER: Yin J 

PROVIDER: S-EPMC12466505 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature