Box-Behnken Design Optimization of Green Extraction from Tomato Aerial Parts and Axillary Shoots for Enhanced Recovery of Rutin and Complementary Bioactive Compounds.

ABSTRACT: Tomato aerial parts and axillary shoots represent underutilized agricultural residues with promising phytochemical potential. Despite the recognized antioxidant capacity of rutin, current literature lacks optimized, comparative studies on its extraction from distinct tomato vegetative components. This study aimed to maximize the recovery of rutin and other bioactive compounds from tomato plant biomass using green extraction techniques-microwave-assisted extraction (MAE) and ultrasound-assisted extraction (UAE)-optimized through Box-Behnken design (BBD) and Response Surface Methodology (RSM). The extraction process was optimized for three key variables: temperature, solvent concentration, and plant-to-solvent ratio. Four main responses were evaluated: total phenolic content (TPC), total fla

SUBMITTER: Marcu Spinu S 

PROVIDER: S-EPMC12466514 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature