Widely Targeted Metabolomics Analysis Reveals Developmental Shifts in Antioxidants and Functional Peptides in <i>Akebia trifoliata</i>.

ABSTRACT: Akebia trifoliata is an emerging fruit crop in China, valued for its medicinal and nutritional properties. To elucidate the developmental dynamics of its bioactive compounds, we performed widely targeted metabolomics using Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS/MS) across four fruit developmental stages (S1-S4). A total of 1595 metabolites were identified, of which 988 were differentially accumulated and categorized into three distinct accumulation patterns. Flavonoids and phenolic acids exhibited a marked decline during fruit maturation, corresponding with decreasing antioxidant and α-glucosidase inhibitory activities. Conversely, functional oligopeptides and specific terpenoids accumulated significantly at later stages. K-means clustering reveale

SUBMITTER: Jia T 

PROVIDER: S-EPMC12466582 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature