Trends in Antituberculosis Drug Resistance and Associated Factors: A 31-Year Observational Study at a Tertiary Hospital in Barcelona.

ABSTRACT: Objective: To analyze trends in resistance to antituberculous drugs over a 31-year period (1991-2022) at a hospital in Barcelona and to identify associated epidemiological determinants. Methods: This study included culture-confirmed tuberculosis cases diagnosed between 1991 and 2022. Drug susceptibility testing was conducted with clinical data from hospital records and epidemiological data from the Barcelona Public Health Agency. The primary outcome was resistance to first-line drugs. A subset of isolates was tested for second-line drugs. Trends were compared between the periods 1991-2000 and 2001-2022, aligning with increased immigration. Factors associated with resistance were examined using multivariate regression analysis. Results: Among the 2448 patients included,

SUBMITTER: Espasa M 

PROVIDER: S-EPMC12466672 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature