<i>miR-194-3</i> Regulates Proliferation and Apoptosis of Follicular Granulosa Cells by Targeting <i>CHD4</i> in Zhedong White Geese.

ABSTRACT: The dynamic balance between proliferation and apoptosis of follicular granulosa cells (GCs) is crucial for follicular development in poultry. microRNAs play important roles in ovarian development and follicular function. Previous transcriptome analyses showed that miR-194-3 was significantly differentially expressed in the ovaries of Zhedong white geese during the laying and brooding stages. Therefore, the aim of this study was to investigate the regulatory role and molecular mechanism of miR-194-3 on the proliferation and apoptosis of follicular GCs in Zhedong white geese. We first screened the target gene CHD4 of miR-194-3 and constructed the miR-194-3 mimic and inhibitor, a small interfering RNA of target gene CHD4. The experimental results show

SUBMITTER: Zheng P 

PROVIDER: S-EPMC12466677 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature