Antimicrobial and Cytoprotective Effects of Tea Extracts Against <i>Escherichia coli</i>-Producing Colibactin Toxin Infections.

ABSTRACT: Background/Objectives: Camellia sinensis (L.) Kuntze or tea contains bioactive compounds such as catechin and caffeine, known for their antimicrobial and health-promoting properties. Colibactin-producing Escherichia coli are linked to genotoxicity in colon epithelial cells, potentially contributing to colorectal disease. This study aimed to evaluate the inhibitory effects of tea extracts (green, oolong, and black) and the phytochemicals catechin and caffeine on E. coli pathogenesis mediated by colibactin toxins, including transient infections, DNA damage, and cell cycle alterations in Caco-2 colon cells. Methods: Tea extracts were analyzed by HPLC for phytochemical content. Their antimicrobial activity against colibactin-producing E. coli (ATCC 259

SUBMITTER: Teppabut W 

PROVIDER: S-EPMC12466732 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature