1,5-Diarylidene-4-Piperidones as Promising Antifungal Candidates Against <i>Cryptococcus neoformans</i>.

ABSTRACT:

Background/objectives

The present study investigates the antifungal potential of 1,5-diarylidene-4-piperidones.

Methods

These compounds were synthesized via Claisen-Schmidt condensation, and their antifungal efficacy was tested against Cryptococcus neoformans, a yeast recently qualified as a critical priority pathogen by the World Health Organization, through determination of their minimum inhibitory concentration (MIC). We designed and synthesized a series of piperidones to explore structure-activity relationships.

Results

Systematic modification of the substituent pattern revealed that tetrabutoxy groups exhibited potent activity (MIC of 7.8 µM), surpassing standard antifungals like fluconazole. The selectivity index (SI) values confirmed their safety profile

SUBMITTER: Courvoisier-Dezord E 

PROVIDER: S-EPMC12466757 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature