General integrated rate law for complex self-assembly reactions reveals the mechanism of amyloid-beta coaggregation.

ABSTRACT: Analyzing kinetic experiments on protein aggregation using integrated rate laws has led to numerous advances in our understanding of the fundamental chemical mechanisms behind amyloidogenic disorders such as Alzheimer's and Parkinson's diseases. However, the description of biologically relevant processes may require rate equations that are too complex to solve using existing methods, hindering mechanistic insights into these processes. An example of significance is coaggregation in environments containing multiple amyloid-beta (Aβ) peptide alloforms, which may play a crucial role in the biochemistry of Alzheimer's disease but whose mechanism is still poorly understood. Here, we use the mathematics of Lie symmetry to derive a general integrated rate law valid for most plausible linear self-

SUBMITTER: Dear AJ 

PROVIDER: S-EPMC12466918 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature