Active learning of neural population dynamics using two-photon holographic optogenetics.

ABSTRACT: Recent advances in techniques for monitoring and perturbing neural populations have greatly enhanced our ability to study circuits in the brain. In particular, two-photon holographic optogenetics now enables precise photostimulation of experimenter-specified groups of individual neurons, while simultaneous two-photon calcium imaging enables the measurement of ongoing and induced activity across the neural population. Despite the enormous space of potential photostimulation patterns and the time-consuming nature of photostimulation experiments, very little algorithmic work has been done to determine the most effective photostimulation patterns for identifying the neural population dynamics. Here, we develop methods to efficiently select which neurons to stimulate such that the resulting neu

SUBMITTER: Wagenmaker A 

PROVIDER: S-EPMC12466919 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature