Artificial Sweeteners in US-Marketed Oral Nicotine Pouch Products: Correlation With Nicotine Contents and Effects on Product Preference.

ABSTRACT:

Introduction

Artificial sweeteners, sucralose and acesulfame-k, are listed as ingredients of oral nicotine pouches (ONPs), a product category with a rapidly growing market share. The exact quantities of these sweeteners in ONPs remain unknown. Artificial sweeteners in ONPs may reduce aversion, facilitate initiation, and encourage consumption behavior.

Aims and methods

Sucralose and acesulfame-k contents in major US-marketed ONP brands (Zyn, on!, and Velo) were determined by liquid chromatography-mass spectrometry. Sweetener effects on aversion and consumption of ONPs were modeled in single- and two-bottle drinking tests, offering mice ONP extracts calibrated to contain nicotine levels similar to the saliva of people who use smokeless tobacco. To examine the contribution of s

SUBMITTER: Jabba SV 

PROVIDER: S-EPMC12466937 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature