The Effects of Microgravity on the Structure and Function of Cardiomyocytes.

ABSTRACT: Spaceflight and microgravity (μg) environments induce numerous cardiovascular changes that affect cardiac structure and function, and understanding these effects is essential for astronaut health and tissue engineering in space. This review compiles and analyzes over 30 years of research on the impact of real and simulated μg on cardiomyocytes. A comprehensive literature search was conducted across five databases, and 62 eligible studies involving cardiac cells under μg or spaceflight conditions were compiled and analyzed. Despite the great heterogeneity in terms of cardiac model, microgravity platform, and exposure duration, multiple studies consistently reported alterations in Ca²⁺ handling, metabolism, contractility, and gene expression. Three-dimensional human-induced plurip

SUBMITTER: Gonzalez-Torres LF 

PROVIDER: S-EPMC12467004 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature