Monolithic multimodal neural probes for sustained stimulation and long-term neural recording.

ABSTRACT: Long-term implantable neural probes with dual-mode optical stimulation and simultaneous electrical recording are crucial for modulating neural loop activity in vivo. Traditional probes using "add-on" strategies often suffer from mechanical rigidity, compromised electrical performance, and insufficient biocompatibility, limiting their clinical applicability. In this study, we present a method for the direct laser writing of electrode arrays onto the curved surface of optical fibers, integrating them within a biocompatible polymer coating to create monolithic neural probes. The monolithic probes demonstrate high mechanical bending endurance, stable impedance, and improved biocompatibility, resulting in a lower inflammatory response compared to conventional systems. Furthermore, our method fa

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12467050 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature