Foreign Body Reaction to Neural Implants: A Comparative Study of Polymer Toxicity and Tissue Response.

ABSTRACT: This study investigated the toxicity of ten polymer materials intended for the development of invasive neural interfaces improving the treatment of neurological diseases. Most of the materials for neural implants can cause traumatization of the surrounding tissue, inflammation, and foreign body reaction. In this study, in vitro and in vivo toxicity assessment was performed for nylon 618 (NY), polycaprolactone (PCL), polyethylene glycol diacrylate (PEGDA), polydimethylsiloxane (PDMS), polyethylene terephthalate (PET), polylactide (PLA), thermoplastic polyurethane (TPU), polypropylene (PP), polyethylene terephthalate glycol (PET-G), and polyimide (PI). The biocompatibility of these ten materials was assessed based on cell adhesion, growth and cytotoxicity on neural (PC-12) and fibroblast (NR

SUBMITTER: Makievskaya C 

PROVIDER: S-EPMC12467080 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature