Overexpression of LIM Homeodomain Gene <i>Arrowhead</i> Induces Pleiotropic Developmental Alterations in the Silkworm, <i>Bombyx mori</i>.

ABSTRACT: LIM homeodomain (LIM-HD) is a versatile family of transcription factors that act as master regulators in various developmental processes of eukaryotes, and one of the LIM-HD encoded genes is the arrowhead (AWH). In silkworm Bombyx mori, the Arrowhead gene (BmAWH) functions as a key component activating all three fibroin genes in the silk glands of B. mori, but the potential pleiotropic effects of BmAWH on various tissues of the silkworm is yet to be discovered. The objective of this study is to investigate the functional role of a BmAWH gene in the B. mori (Dazao) developmental process, using the piggyBac-based transgene technique. The size of transgenic line silk glands have become smaller, resulting in the reduction in whole

SUBMITTER: Idris NFB 

PROVIDER: S-EPMC12467131 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature