Comprehensive Genome Analysis of Two Bioactive <i>Brevibacterium</i> Strains Isolated from Marine Sponges from the Red Sea.

ABSTRACT: Marine-derived Actinomycetota have emerged as promising sources of bioactive natural products, particularly filamentous actinomycetes (e.g., Streptomyces). However, members from non-filamentous genera have showed potential biotechnological importance. In this study, we performed a comprehensive genomic characterization of two bioactive Brevibacterium strains, Brevibacterium luteolum (B. luteolum) 26C and Brevibacterium casei (B. casei) 13A, isolated from two Red Sea sponges. Whole-genome sequencing and taxonomic analysis confirmed species-level identification, marking the first documented report of these species within the Red Sea ecosystem. The two strains displayed antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Can

SUBMITTER: Mohamed YS 

PROVIDER: S-EPMC12467314 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature