Placental Morphology and Metabolomic Profile in Uncomplicated Metabolically Healthy Obese Pregnancy.

ABSTRACT: Background/Objectives: Individuals with metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) in pregnancy are two distinct cardiometabolic populations, each potentially necessitating alternative clinical management. However, our understanding of the unique physiological effects of uncomplicated MHO on fetoplacental growth and metabolism remains limited. In this study, we aimed to identify changes in placental morphology and metabolites associated with maternal obesity, independent of pregnancy-related cardiometabolic complications. Methods: Placentae from women with a prepregnancy body mass index (BMI) < 25 kg/m² (control; n = 15) and women with MHO (prepregnancy BMI > 30 kg/m² with no cardiometabolic diseases; n =

SUBMITTER: Sarr O 

PROVIDER: S-EPMC12467361 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature