Comparative evaluation of amoxicillin loading and release behavior from waste-derived hydroxyapatite synthesized by solid-state and wet chemical routes.

ABSTRACT: This study presents a comparative analysis of amoxicillin loading and release behaviors of hydroxyapatite (HAp) synthesized by two methods, solid-state reaction (S-HAp1000) and wet chemical precipitation (W-HAp1000) using waste chicken eggshells as the calcium source and calcination at 1000 °C for 2 hours. Structural and morphological characterization revealed significant differences: S-HAp1000 exhibited a biphasic composition with 75.5% HAp and 24.5% β-TCP based on Rietveld refinement, larger crystallite size (88 nm), and higher amoxicillin entrapment efficiency (11.63%), while W-HAp1000 exhibited 99.6% phase-pure HAp, smaller crystallite size (83 nm), and lower entrapment efficiency (7.28%). Drug release in simulated body fluid (SBF) at pH 7.4 and 4.0 showed that W-HAp1000 released 62.96

SUBMITTER: Mobarak MB 

PROVIDER: S-EPMC12467588 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature