Chemical Deuteration of α-Amino Acids and Optical Resolution: Overview of Research Developments.

ABSTRACT: Deuterium-labelled amino acids have found extensive applications in such research areas as pharmaceutical, bioanalytical, neutron diffraction, inelastic neutron scattering, in analysis of drug metabolism using mass spectrometry (MS), and, structuring of biomolecules by NMR. For these reasons, interest in new methodologies for the deuterium labelling of amino acids and the extent of their applications are equally rising. The ideal method will be able to label target compounds rapidly and cost-effectively by the direct exchange of a hydrogen atom by a deuterium atom. Most of these exchange reactions can often be carried out directly on the final target compound or a late intermediate in the synthesis, and often D₂O can be used as the deuterium source. This review aims to provide a

SUBMITTER: Yepuri NR 

PROVIDER: S-EPMC12467683 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature