Sex-Stratified Prediction Models for 5-Year Nonalcoholic Fatty Liver Disease Risk in Thyroid Cancer Patients: A Nationwide Cohort Study.

ABSTRACT: Background/Objectives: Nonalcoholic fatty liver disease (NAFLD) is a significant complication among survivors of thyroid cancer; however, existing prediction models for NAFLD remain inadequate. Our objective was to develop survival prediction models for 5-year risk of NAFLD in patients diagnosed with thyroid cancer. Methods: Utilizing the Korean National Health Insurance Service claims database, we selected 3644 post-thyroidectomy patients with thyroid cancer between 2004 and 2014. Following a 7:3 stratified division into training and test datasets, we developed sex-stratified survival models using random survival forest (RSF) and Cox proportional hazards regression (Cox). The evaluation of prediction models was performed using Harrell's concordance index (C-index), time-depe

SUBMITTER: Cho YB 

PROVIDER: S-EPMC12467750 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature