Transcriptomic Profile of Isocitrate Dehydrogenase Mutant Type of Lower-Grade Glioma Reveals Molecular Changes for Prognosis.

ABSTRACT: Background/Objectives: Lower-grade glioma (LGG) is a type of brain tumor with a relatively better prognosis than glioblastoma. However, identifying therapeutic targets for LGGs remains elusive. To uncover the molecular features of LGGs, functional genomics data have been investigated. Methods: Using public transcriptomics data of LGGs (The Cancer Genome Atlas and GSE107850), differentially expressed genes (DEGs) and differentially co-expressed (DCE) gene pairs between IDH mutation statuses were determined. Gene set enrichment analysis identified the molecular mechanisms of isocitrate dehydrogenase (IDH) mutation in LGGs. Furthermore, the identified DEGs and DCE gene pairs were used for drug repurposing analysis. Results: Two public datasets revealed an overlap of 1527

SUBMITTER: Cho SB 

PROVIDER: S-EPMC12467759 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature