Defining a Simplified Process in Yeast for Production of Enveloped VLP Dengue Vaccine.

ABSTRACT: Dengue is a rapidly spreading mosquito-borne viral infection, with increasing reports of outbreaks globally. According to the World Health Organization (WHO), by 30 April 2024, over 7.6 million dengue cases were reported, including 3.4 million confirmed cases, more than 16,000 severe cases, and over 3000 deaths. As dengue remains endemic in many regions, there is a critical need for the development of new vaccines and manufacturing processes that are efficient, cost-effective, and capable of meeting growing demand. In this study, we explore an alternative process development pathway for the future manufacturing of a dengue vaccine, utilizing Komagataella phaffii (Pichia pastoris) as the host organism, one of the most promising candidates for the expression of heterologous pro

SUBMITTER: de Sa Magalhaes S 

PROVIDER: S-EPMC12467798 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature