StemBell Therapy Does Not Significantly Affect Atherosclerotic Plaque Characteristics in a Streptozotocin-Induced Diabetes Mellitus Mouse Model.

ABSTRACT:

Aims

Diabetes mellitus (DM) increases cardiovascular risk by inducing atherosclerotic plaque instability. StemBell therapy (i.e., adipose tissue-derived stem cells (ASCs) coupled to ultrasound-activated microbubbles) previously improved plaque stability in non-DM ApoE^-/- mice. Here, we investigated the effect of StemBell therapy on atherosclerotic plaque characteristics in a streptozotocin-induced DM mouse model.

Methods

DM was induced in male C57BL/6 ApoE^-/- mice (n = 18) via intraperitoneal streptozotocin (STZ) injection (0.05 mg/g bodyweight) for 5 consecutive days. Eight weeks after the first STZ injection, the mice received either 5 × 10⁵ StemBells or vehicle intravenously. Due to unexpected mortality, the experiment was halted an

SUBMITTER: Korn A 

PROVIDER: S-EPMC12467836 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature