Tyrosine Hydroxylase-Expressing Neurons in the Vagal Ganglia: Characterization and Implications.

ABSTRACT: Background/Objectives: A combination of sympathoexcitation and parasympathetic withdrawal contributes to the occurrence of ventricular arrhythmias, sudden cardiac death, and progression of heart failure after myocardial injury. As a result, vagal nerve stimulation has been under investigation as a potential option to increase cardiac vagal tone, but the results of clinical trials have been mixed. Prior studies have suggested that the vagal ganglia and nerves may contain sympathetic neurons that express tyrosine hydroxylase (TH), which, if stimulated, could potentially mitigate the effects of vagal nerve stimulation. The goal of the current study was to better characterize these neurons. Methods: Immunohistochemical staining was performed to evaluate for the presence of TH-exp

SUBMITTER: Khaky A 

PROVIDER: S-EPMC12467911 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature