<i>DRD2</i> Ex8 rs6276 Polymorphism and NEO-FFI Personality Traits in Elite Athletes and Controls.

ABSTRACT: Background/Objectives: Personality traits influence motivation, self-regulation, and adaptation in high-performance sports, and are partially modulated by dopaminergic genetic variability. This study aimed to examine the association between the DRD2 Ex8 rs6276 polymorphism and NEO Five-Factor Inventory (NEO-FFI) personality traits in elite athletes and non-athlete controls. Methods: A total of 323 participants were included: 141 athletes and 182 controls. Genomic DNA was isolated from venous blood, and DRD2 Ex8 rs6276 genotypes (A/A, A/G, G/G) were determined using real-time PCR with melting-curve analysis. Personality traits were assessed using the NEO-FFI, and group differences as well as genotype × group interactions were evaluated using multivariate analyses

SUBMITTER: Reclaw R 

PROVIDER: S-EPMC12467987 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature