Photoinduced Inhibition of Neutrophil Extracellular Traps Formation by Dichromatic Light Irradiation.

ABSTRACT: Neutrophils are the first line of defense of the human immune system against pathogens. Photobiomodulation, mediated by mitochondrial photoacceptors such as cytochrome c oxidase, has emerged as a method to modulate neutrophil function through targeted light exposure. Despite the extensive characterization of neutrophil extracellular traps (NETs) formation (NETosis), the wavelength-specific modulation of neutrophil photoactivation and the involvement of redox pathways remain poorly defined. In this study, the effects of monochromatic (365 nm, 415 nm, 437 nm, and 625 nm) and dichromatic LED-light irradiation on NETs formation were systematically examined. The highest netotic responses were elicited by UV-A (365 nm) and violet-blue light (415 nm), whereas 437 nm showed the lowest induc

SUBMITTER: Mamatkulov K 

PROVIDER: S-EPMC12468020 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature