Elevated Mean Corpuscular Hemoglobin Concentration as a Potential Peripheral Biomarker of Parkinson's Disease: A Pilot Case-Control Study in a Mexican Population.

ABSTRACT: Background: Alterations in peripheral red blood cell (RBC) indices have been proposed as potential biomarkers for Parkinson's disease (PD), but their diagnostic utility and relation to clinical features remain uncertain. Methods: We conducted a pilot case-control study involving 70 PD patients and 122 controls from two neurology centers in Mexico. Standardized hematology analyses provided RBC indices, and neuropsychiatric assessments included the Hamilton Depression Rating Scale (HAM-D) and Mini-Mental State Examination (MMSE). Associations between RBC indices and PD were tested using multivariable logistic regression adjusted for age, sex, and smoking. Diagnostic performance was evaluated by receiver operating characteristic (ROC) curve analysis. Subgroup analyses stratified

SUBMITTER: Miranda-Morales EG 

PROVIDER: S-EPMC12468377 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature