Revealing the Angiogenic Signature of <i>FH</i>-Deficient Breast Cancer: Genomic Profiling and Clinical Implications.

ABSTRACT: Background: Fumarate hydratase (FH) deficiency is a rare metabolic alteration in breast cancer that may drive tumor progression through angiogenic remodeling. However, its role in shaping the tumor microenvironment remains poorly defined, limiting our understanding of metabolism-driven angiogenesis and its therapeutic significance. Methods: We analyzed genomic and transcriptomic profiles from thousands of breast cancer samples, including the TCGA cohort, to identify FH mutations and copy number alterations. Differential expression, pathway enrichment, and weighted gene co-expression network analysis (WGCNA) were performed to characterize metabolic and signaling changes. Clinical relevance was examined in a triple-negative breast cancer patient with an FH

SUBMITTER: Sinberger LA 

PROVIDER: S-EPMC12468410 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature