Bioactive Component Screening and Mechanistic Study of the Anti-Diabetic Activity of <i>Lophatherum gracile</i> Brongn Extract.

ABSTRACT: Type 2 diabetes mellitus (T2DM), a metabolic disorder defined by glucose and lipid metabolism dysregulation, has become a major global health issue. Hence, effective measures to prevent T2DM are urgently required. Lophatherum gracile Brongn (LGB) has been used in managing diabetes-related systemic diseases. However, the hypoglycemic bioactive components in LGB and the mechanisms underlying their hypoglycemic activity remain elusive. The current study sought to characterize the bioactive components of LGB and elucidate its mechanism of action against T2DM. Six common characteristic peaks were identified from six batches of LGB, with 39 characteristic chemical components preliminarily identified. Through component-activity correlation analysis, three functional components-namely isoor

SUBMITTER: Wang R 

PROVIDER: S-EPMC12468491 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature