Exploring CCND1 as a Key Target of <i>Acorus calamus</i> Against RSV Infection: Network Pharmacology, Molecular Docking, and Bioinformatics Analysis.

ABSTRACT: Acorus calamus, a traditional Tibetan medicine with potential antiviral activity but undefined mechanisms, was studied for its anti-respiratory syncytial virus (RSV) mechanisms using network pharmacology and molecular docking, given RSV's substantial disease burden and lack of specific therapies. The primary active compounds were identified and analyzed through a literature search, the PubChem database, and the SwissADME. Relevant targets were sifted through the SwissTargetPrediction platform, OMIM, and GeneCards databases. Common targets underwent enrichment analysis using Disease Ontology (DO), Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG). Molecular docking and GEO datasets were used for further analysis. Among the screened data, 268 targets were associat

SUBMITTER: Chang H 

PROVIDER: S-EPMC12468655 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature