Salivary Biomarker Analysis to Distinguish Between Health and Periodontitis Status: A Preliminary Study.

ABSTRACT: Objective: This study aims to explore the feasibility of a non-invasive and simple method for discriminating between health and periodontitis (PRD), facilitating early and objective diagnosis of PRD before detectable periodontal attachment loss and monitoring treatment outcomes. Methods: Salivary samples were collected from 16 PRD-free patients (G1) and 10 patients with PRD (G2). The analysis included salivary matrix metalloproteinase-8 (MMP-8), major anti-inflammatory interleukins (IL-4 and IL-10), pro-inflammatory cytokines (IL-1β, IL-8, and interferon α [IFN-α]), and the cytokine IL-6. Clinical and salivary assessments were performed at baseline (TP0) for both groups and after periodontal treatment for G2 (TP1). Results: PRD indices were significantly higher in G2-T

SUBMITTER: Bertoldi C 

PROVIDER: S-EPMC12468743 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature