New chalcone compound exhibits microrna-mediated anticancer properties in glioblastoma.

ABSTRACT:

Background

Therapy-resistant glioblastoma constitutes the most lethal adult brain malignancy, bearing extremely poor patients' prognosis. Combinational therapies are accompanied by severe side effects and significant financial burden, highlighting the urgent need for alternative, low toxicity treatments. This study sought to investigate the therapeutic efficacy of a new synthetic chalcone molecule, SHG-44, and its cellular mechanistic actions in U87MG and U251MG glioblastoma cell line models.

Methods

The effect of SHG-44 on glioblastoma cell viability, clonogenic survival, and cell migration was assessed using in vitro functional assays. Cellular reactive oxygen species levels were quantified to investigate oxidative stress induced by SHG-44. The induction of apoptosis by SH

SUBMITTER: Mustafov D 

PROVIDER: S-EPMC12468763 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature