Relationship between anion gap and 28-day all-cause mortality in patients with acute pulmonary edema: A retrospective analysis of the MIMIC-IV database.

ABSTRACT:

Background

Acute pulmonary edema is a severe clinical condition with high mortality. The anion gap, reflecting metabolic acid-base disturbances, is often elevated in critically ill patients. However, its relationship with outcomes in acute pulmonary edema remains unclear.

Objective

To explore the association between admission anion gap levels and 28-day all-cause mortality in patients with acute pulmonary edema.

Methods

This retrospective cohort study utilized data from the MIMIC-IV database (2008-2019) and included adult patients with acute pulmonary edema. Patients were categorized into quartiles based on anion gap levels. Cox regression models analyzed the relationship between anion gap and mortality, with restricted cubic spline (RCS) curves, Kaplan-Meier analysis

SUBMITTER: Guo P 

PROVIDER: S-EPMC12468886 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature