Clinical, laboratory and genetic factors associated with smoking in a Brazilian Sickle Cell Disease (SCD) cohort.

ABSTRACT:

Background

Smoking is associated with increased morbidity among individuals with sickle cell disease (SCD). While genetic factors influencing smoking behavior have been identified in other populations, they have not been studied in individuals with SCD. This study aimed to assess the impact of smoking on clinical and laboratory parameters in a large SCD cohort and to identify genetic variants potentially associated with smoking behavior in this population.

Methods

The Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) Brazil SCD cohort was established across six Brazilian cities to investigate clinical outcomes in individuals with SCD. Adult participants were interviewed and asked whether they had ever smoked more than 100 cigarettes in their lifetime. Those wh

SUBMITTER: Cruz T 

PROVIDER: S-EPMC12469115 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature