Changes in Gut Microbial Diversity and Correlation with Clinical Outcome in Children with Acute Myeloid Leukemia Receiving Induction Chemotherapy.

ABSTRACT: Background: The gut microbiome affects human health, and patients with cancer are no exception. In those patients, intensive chemotherapy impairs gut barrier integrity, causing dysbiosis, bacterial translocation, and higher infection risk. Objectives: This prospective study, conducted at Children's Cancer Hospital in Egypt, profiles the microbiome of 29 pediatric patients with AML, and examines how induction chemotherapy and antibiotics affect their microbiome. Methods: Gut microbiome changes were evaluated before treatment (T1), then 7 (T2) and 21-28 days (T3) from induction start. Microbial DNA, extracted from rectal swabs or stool samples, was subjected to 16S rRNA amplicon sequencing, followed by bioinformatics and statistical analyses. Results: Treatment si

SUBMITTER: Adel M 

PROVIDER: S-EPMC12469140 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature