Modelling the relative contribution of infection, routine vaccination and supplementary immunisation activities to measles seroconversion in Kenyan Children.

ABSTRACT:

Background

Measles outbreaks continue to cause a large burden of disease in Africa including Kenya. We used information from regular serological surveys in Kilifi Health and Demographic Surveillance System (KHDSS) in combination with mathematical modelling to estimate the relative contribution of the vaccination programme to current measles immunity.

Methods

We developed a static birth cohort model to track the proportion of children who are either measles naïve or seroconverted due to natural infection or vaccination through first dose of measles-containing vaccine (MCV1), the second dose (MCV2), or supplementary immunisation activities (SIAs). We fitted the model to biennial paediatric serological survey and case notification data and used vaccination coverage estimates fr

SUBMITTER: Mburu C 

PROVIDER: S-EPMC12469164 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature