Deep Sequencing Reveals Novel Mutations in <i>Androgen Receptor</i>-Related Genes in Prostate Cancer.

ABSTRACT: Prostate cancer (PCa) is the second most frequent tumor and the fifth leading cause of cancer-related death in men worldwide. PCa shows the largest clinical disparities across Asian, Caucasian, and African descendants among all cancer types, proving that the ethnic genetic background plays a significant role in PCa. Androgen Receptor (AR) gene malfunctioning represents the most prevalent cause of PCa. AR also displays a broad spectrum of genetic variability across ethnic backgrounds differently associated with cancer risk. We conducted a massive sequencing analysis of 15 genes highly relevant for PCa or the AR activation pathway in biopsies from 64 tumors and 36 benign prostate samples from Mexican patients. We identified 3414 genomic mutations and observed that AR<

SUBMITTER: Pedroza-Torres A 

PROVIDER: S-EPMC12469278 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature