Computational and Experimental Insights into Tyrosinase and Antioxidant Activities of Resveratrol and Its Derivatives: Molecular Docking, Molecular Dynamics Simulation, DFT Calculation, and In Vitro Evaluation.

ABSTRACT: Resveratrol, a natural stilbene found in various plants, is mainly known for its strong antioxidant activities exhibiting a comprehensive range of treatments for some skin disorders such as skin cancer, photoaging, dermatitis, and melanogenesis. However, few studies have been conducted on the differences in biological activities between resveratrol and its derivatives. Therefore, we aimed to investigate the effects of resveratrol (Re) and its derivatives acetyl-resveratrol (Are), cis-trismethoxy resveratrol (Cre), dihydroresveratrol (Dre), and oxyresveratrol (Ore) on antioxidant and anti-tyrosinase effects using in vitro and in silico methods. In the in vitro results, Ore showed the highest antioxidant activity among the resveratrol derivatives and

SUBMITTER: Sripadung P 

PROVIDER: S-EPMC12469314 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature