Selenoprotein S and the Causal Risk of Hypertension in Pregnancy: A Mendelian Randomization Study.

ABSTRACT: Background: Pregnancy-induced hypertension (PIH) affects approximately 10% of pregnancies worldwide, representing a leading cause of maternal and perinatal morbidity and mortality. The relationship between plasma selenium levels and PIH remains controversial, with observational studies limited by confounding factors. Selenoprotein S (SELENOS) has emerged as a potential biomarker for PIH risk. As one of the carrier proteins for dietary selenium, SELENOS plays a crucial role in oxidative stress and inflammatory pathways. However, the causal relationship between the plasma levels of the SELENOS and PIH development remains unclear. This study employed Mendelian randomization (MR) to investigate the causal link between the plasma levels of the SELENOS and PIH risk, providing evidence for

SUBMITTER: Cai M 

PROVIDER: S-EPMC12469401 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature