Multi-SNP Haplotypes in Circadian <i>PER3</i> Gene Are Associated with Mood and Sleep Disorders in University Students.

ABSTRACT: Background: Mood disorders, including anxiety, depression, and seasonal affective disorder (SAD), are often comorbid and can be exacerbated by the misalignment of an individual's circadian rhythm with their social timing. Single-nucleotide polymorphisms (SNPs) in circadian clock genes have been associated with both internalizing disorders and sleep disturbances, and some clock polymorphisms, including those in the Period3 (PER3) gene, likely function via delaying or advancing circadian period and affecting sleep-wake patterns. Methods: Here, we explore associations of multiple SNP haplotypes in the PER3 gene with anxiety, depression, internalizing disorder (ID), chronotype, and sleep disturbance in young adults (n = 1109 individuals). Results: We r

SUBMITTER: Goodell F 

PROVIDER: S-EPMC12469539 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature